Excedrin Extra Strength Caplets provide headache relief fast. Excedrin works in 3 ways: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance pain relief. The caplets combine aspirin, acetaminophen and caffeine. It has two pain relievers and a booster to offer relief of headaches, cramps, tooth pain and more. Get headache relief fast with Excedrin, the headache expert. One bottle of 100 Excedrin Extra Strength Pain Relief Caplets Extra strength pain reliever that relieves pain associated with headache, colds, menstrual cramps, toothaches, muscle pain and arthritis Excedrin Extra Strength works in 3 ways: it blocks pain signals, elevates your pain threshold and uses caffeine to enhance pain relief effect Pain medicine for adults that is a clinically proven headache pain reliever Excedrin Extra Strength caplets contain two pain relievers and a booster for enhanced effect