Prions and Diseases - by Wen-Quan Zou & Pierluigi Gambetti (Hardcover)
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<p/><br></br><p><b> About the Book </b></p></br></br>Volume II covers the etiology, pathogenesis, classification, histopathological and clinical aspects of animal and human prion diseases, including decontamination of prions and development of therapeutics for prion diseases, such as immunomodulation.<p/><br></br><p><b> Book Synopsis </b></p></br></br><p>Chapter 1 Bovine Spongiform Encephalopathy<br>Gianluigi Zanusso, Salvatore Monaco</p><p>Chapter 2 Classical and Atypical Scrapie in Sheep and Goats<br>Christine Fast, Martin H. Groschup</p><p>Chapter 3 Chronic wasting disease and the development of research models<b><br></b>Glenn Telling</p><p>Chapter 4 Sporadic Human Prion Disease<br>Pierluigi Gambetti</p><p>Chapter 5 Environmentally-acquired Transmissible Spongiform Encephalopathy<br>Paul Brown</p><p>Chapter 6 Prions in the Environment<br>Shannon L. Bartelt-Hunt, Jason C. Bartz, Samuel E. Saunders</p><p>Chapter 7 The Spectrum of Tau Pathology in Human Prion Disease<br>Gabor G. Kovacs, Herbert Budka</p><p>Chapter 8 Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion<br>Alexander H. Peden, Mark W. Head, James W. Ironside</p><p>Chapter 9 Species Barriers in Prion Disease<br>Suzette A. Priola</p><p>Chapter 10 Transgenic Mice Modelling<br>Abigail B. Diack, Rona Wilson, Enrico Cancellotti, Barry Bradford, Matthew Bishop, Jean C. Manson</p><p>Chapter 11 Prion Transmission Studies in Transgenic Mice<br>Qingzhong Kong <p/>Chapter 12 Alternative Models of Prion Diseases<br>Pedro Fernandez-Funez, Edward Málaga-Trillo, Diego E. Rincon-Limas</p><p>Chapter 13 Diagnosis of Prion Disease: Conventional Approaches<br>Inga Zerr, Joanna Gawinecka, Katharina Stoeck, Maren Breithaupt</p><p>Chapter 14 Quaking-induced Conversion (QuIC) Assays for the Detection and Diagnosis of Prion Diseases<br>Jason M. Wilham, Christina D. Orrù, Sarah Vascellari, Andrew G. Hughson, Byron Caughey</p><p>Chapter 15 The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context<br>T. Dean Airey, and Neil R. Cashman</p><p>Chapter 16 Overview on Treatment of Prion Diseases and Decontamination of Prions<br>Richard Knight</p><p>Chapter 17 Immunomodulation<br />Thomas Wisniewski, Fernando Goñi</p><p/><br></br><p><b> From the Back Cover </b></p></br></br><p>Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named <i>prion</i> or scrapie PrP (PrP<sup>Sc</sup>), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.</p><p>Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.</p>
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