Veronica (Sandra Oh) and Ashley (Anne Heche) were good friends in college, but now find themselves in very different walks of life. Veronica has become the entitled, wine-loving wife of a rich businessman, while Ashley, along with her lover Lisa (Alicia Silverstone), struggles to make ends meet as an artist. When they bump into each other at a fancy cocktail party, what starts as a friendly conversation quickly turns caustic before erupting into a vicious, bloody fight that will change both of their lives forever.