<p/><br></br><p><b> About the Book </b></p></br></br>The thoroughly revised and expanded third edition of this highly praised book includes new material on automation, updates on hematopoietic neoplasms reflecting WHO guidelines, coverage of regulatory changes and a chapter on advances in chromosone microarray.<p/><br></br><p><b> Book Synopsis </b></p></br></br><p>SECTION 1 - Basic Concepts and Background<br>1. History of Clinical Cytogenetics<br>Steven L. Gersen</p><p>2. DNA, Chromosomes, and Cell Division <br>Martha B. Keagle</p><p>3. Human Chromosome Nomenclature: An Overview and Definition of Terms<br>Marilyn L. Slovak, Aaron Theisen, and Lisa G. Shaffer</p><p>SECTION II - Examining and Analyzing Chromosomes<br>4. Basic Cytogenetics Laboratory Procedures<br>Martha B. Keagle and Steven L. Gersen</p><p>5. The Essentials of Light Microscopy<br>Nathan Claxton and Stephen Ross</p><p>6. Quality Control & Quality Assurance<br>Martha B. Keagle</p><p>7. Instrumentation in the Cytogenetics Laboratory<br>Steven L. Gersen</p><p>SECTION III - Clinical Cytogenetics<br>8. Autosomal Aneuploidy<br>Jin-Chen C. Wang</p><p>9. Structural Chromosome Rearrangements<br>Kathleen Kaiser-Rogers and Kathleen Rao</p><p>10. Sex Chromosomes, Sex Chromosome Disorders, and Disorders of Sex Development<br>Cynthia M. Powell</p><p>11. The Cytogenetics of Infertility<br>Linda Marie Randolph</p><p>12. Prenatal Cytogenetics<br>Linda Marie Randolph</p><p>13. The Cytogenetics of Spontaneous Abortion<br>Solveig M. V. Pflueger</p><p>14. Chromosome Instability<br>Xiao-Xiang Zhang</p><p>SECTION IV - Cancer Cytogenetics<br>15. The Cytogenetics of Hematologic Neoplasms<br>Aurelia Meloni-Ehrig</p><p>16. The Cytogenetics of Solid Tumors <br>Linda D. Cooley and Kathleen S. Wilson</p><p>SECTION V - Adjunct Technologies<br>17. Fluorescence in situ Hybridization (FISH)<br>Daynna J. Wolff</p><p>18. Microarray-Based Cytogenetics<br>Lisa G. Shaffer</p><p>SECTION VI - Beyond Chromosomes<br>19. Fragile X: A Family of Disorders: Changing Phenotype and Molecular Genetics<br>Elaine B. Spector </p><p>20. Genomic Imprinting and Uniparental Disomy<br>Jin-Chen C. Wang</p><p>21. Genetic Counseling<br>Sarah Hutchings Clark</p><p/><br></br><p><b> From the Back Cover </b></p></br></br><p>In this thoroughly revised and expanded third edition of the highly praised classic, <i>The Principles of Clinical Cytogenetics</i>, a panel of hands-on experts update their descriptions of the basic concepts and interpretations involved in chromosome analysis to include the many advances that have occurred in the field. Among the highlights are a full chapter devoted to advances in chromosome microarray, soon to become a standard of care in this field, as well as an update on chromosome nomenclature as reflected in ISCN 2009. Other features include an update on automation to reflect the current state of the art, an update on hematopoietic neoplasms to reflect the new WHO guidelines, and updates on all regulatory changes that have been implemented. </p><p>Cutting edge and readily accessible, <i>The Principles of Clinical Cytogenetics, Third Edition</i> offers physicians who depend on the cytogenetics laboratory for the diagnosis of their patients, students in cytogenetics programs, graduate and medical students studying for board examinations, cytogenetics technologists, and cytogeneticists a clear understanding of what happens in the cytogenetics laboratory to facilitate accurate and timely diagnoses.</p><p/><br></br><p><b> Review Quotes </b></p></br></br><br><p>From the reviews of the third edition: </p><p>"The audience includes those performing clinical cytogenetic testing or using results for genetic counseling or clinical care. It also would be of interest to anyone interested in cytogenetic analysis and application, from healthcare providers ... to the educated lay public. ... This is truly a remarkable and comprehensive book on clinical cytogenetics. ... You would also want this book as a handy reference for which genetic abnormality is associated with what disease, and the best test method to use to identify the suspected abnormality." (Valerie Ng, Doody's Book Reviews, July, 2013)</p><br><p/><br></br><p><b> About the Author </b></p></br></br><p>Steven L. Gersen, Ph.D.<br>AmeriPath Northeast, Shelton, CT, USA</p><p>Martha B. Keagle, M.Ed.<br>School of Agriculture, University of Connecticut, Storrs, CT, USA<br></p>