Compare to the active ingredient of Tylenol 8HR Arthritis Pain. Don’t let arthritis pain in your joints slow down your lifestyle. Up&Up Acetaminophen Extended-Release Tablets, 650 mg provide up to 8 hours of arthritis pain relief. Just one dose helps to temporarily reduce fever and relieve minor aches and pains due to minor pain of arthritis, muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache and toothache. These extended-release formula caplets (capsule-shaped tablets) do not contain aspirin and are gluten free. This product features a package with an easy-to-open cap for households without young children.